高顶顶

博士 副研究员

创新中药研究院 手性药物研究中心

上海中医药大学

地址:上海市浦东新区蔡伦路1200号

电话:

gaodingding@shutcm.edu.cn

  • 研究内容

    • 基于靶标的创新药物研究

  • 工作经历

    • 2021.1−目前

      副研究员, 上海中医药大学 创新中药研究院 手性药物研究中心

    • 2020.7−2020.12

      助理研究员, 上海中医药大学 创新中药研究院 手性药物研究中心

    • 2018.7−2020.6

      师资博士后, 上海中医药大学 合作导师:林国强 研究员(院士)

  • 教育背景

    • 2012.9-2018.6

      博士,复旦大学 药学院,药物化学专业 (导师:李英霞 教授)

    • 2008.9−2012.6

      本科,郑州大学 药学院,药物制剂专业

  • 学术荣誉

    • 上海中医药大学“杏林青年学者” 2020

    • 上海中医药大学“十大杏林菁英” 2020

    • 上海市青年科技英才“扬帆计划” 2019

  • 主持科研项目

    • 1. 中国博士后科学基金面上项目(2018M642064)

    • 2. 上海市青年科技英才扬帆计划(19YF1449300,2019.052022.04)

    • 3. 国家自然科学基金青年基金(81903423,2020.012022.12)

    • 4. 上海中医药大学预算内项目(A1-GY0309)

  • 代表性论文

    • 11. Jia-Ying Zhao, Kai-Rui Feng, Feng Wang, Jian-Wei Zhang, Jay Fei Cheng,* Guo-Qiang Lin, Dingding Gao,* and Ping Tian*   A Retrospective Overview of PHGDH and Its Inhibitors for Regulating Cancer Metabolism. Eur. J. Med. Chem.  2021,217, 113379. (IF 5.572)

    • 10. Qing-Hua Li,# Dingding Gao,# Cheng-Yu He, Qi Liao, Yun-Xuan Tan, Yu-Hui Wang,* Rui Ding,* Guo-Qiang Lin, and Ping Tian*   One-Pot Preparation of Bridged Tricyclic and Fused Tetracyclic Scaffolds via Rhodium(III)-Catalyzed Asymmetric Borylative Cyclization. Cell Reports Physical Science 2020,1, 100222.

    • 9.Cheng-Yu He#, Yun-Xuan Tan#, Xin Wang, Rui Ding, Yi-Fan Wang, Feng Wang, Dingding Gao*, Ping Tian *, and Guo-Qiang Lin*  Copper(I)-Catalyzed Diastereo- and Enantioselective Construction of Optically Pure Exocyclic Allenes. Nat. Commun. 202011, 4293. (IF 12.121)

    • 8.Dingding Gao#, Xing-Yu Liu#, Hao Xu#, Yun-Xuan Tan, Qi Liao, Qing-Hua Li*, Xiaodi Yang, Guo-Qiang Lin*, and Ping Tian*  One-Pot Preparation of 9,10-Dihydrophenanthrenes Initiated by Rhodium(III)-Catalyzed C−H Activation and Relay Diels-Alder Reaction. Org. Lett. 2020, 22, 4300−4305. (IF 6.091)

    • 7.Kai-Rui Feng#, Feng Wang#, Xin-Wei Shi, Yun-Xuan Tan, Jia-Ying Zhao, Jian-Wei Zhang, Qing-Hua Li*, Guo-Qiang Lin, Dingding Gao*, and Ping Tian*  Design, synthesis and biological evaluation of novel potent STAT3 inhibitors based on BBI608 for cancer therapy. Eur. J. Med. Chem., 2020, 201, 112428. (IF 5.572)

    • 6.Dingding Gao#, Feng Wang#, Xing-Yu Liu, Kai-Rui Feng, Jia-Ying Zhao, Yu-Hui Wang*, Xiao-Di Yang*, Ping Tian*, and Guo-Qiang Lin  Synthesis of Decahydrocyclobuta[cd]indene Skeleton: Rhodium(III)-Catalyzed Hydroarylaton and Relay Thiophene-Promoted Intramolecular [2 + 2] Cycloaddition. Adv. Synth. Catal. 2020, 362, 4384–4390. (IF 5.851)

    • 5.Jun-Li Zhang#, Dingding Gao#, Yun-Xuan Tan, Cheng-Yu He, Pei-Ying Peng, Guo-Qiang Lin, Qing-Hua Li*, Ping Tian*  Rhodium(III)-Catalyzed Kinetic Resolution of Racemic 1,6-Dienes via Asymmetric Borylative Cyclization. Org. Lett. 2020, 22, 3661-3666. (IF 6.091)

    • 4.Ming-Shun Mei#, Yu-Hui Wang#, Qing Hu, Qing-Hua Li, Da-Yu Shi, Dingding Gao,* Guangbo Ge,* Guo-Qiang Lin, and Ping Tian*   Enantioselective [3 + 2] Annulation of Isatin-Derived MBH-Carbonates and 3-Nitroindoles Enabled by a Bifunctional DMAP-Thiourea. Chem. Commun. 2020, 56, 10718-10721. (IF 5.996)

    • 3.Bingbing Zhang#, Jiami Liu#, Dingding Gao#, Xiaolin Yu, Jinlei Wang, Xinsheng Lei*  A fluorine scan on the Zn2+-binding thiolate side chain of HDAC inhibitor largazole: Synthesis, biological evaluation, and molecular modeling. Eur. J. Med. Chem. 2019182, 111672. (IF 5.572)

    • 2.Dingding Gao#, Huixia Dou#, Haixia Su#, Mingming Zhang#, Ting Wang, Qiufeng Liu, Haiyan Cai, Zhuo Yang, Weiliang Zhu*, Yechun Xu*, Heyao Wang*, Yingxia Li*  From Hit to Lead: Structure-based Discovery of Naphthalene-1-Sulfonamide Derivatives as Potent and Selective Inhibitors of Fatty Acid Binding Protein 4. Eur. J. Med. Chem. 2018154, 44-59. (IF 5.572)

    • 1.Haiyan Cai#, Qiufeng Liu#, Dingding Gao#, Ting Wang, Tiantian Chen,Guirui Yan, Kaixian Chen, Yechun Xu*, Heyao Wang*, Yingxia Li*, Weiliang Zhu*  Novel fatty acid binding protein 4 (FABP4) inhibitors: Virtual screening, synthesis and crystal structure determination. Eur. J. Med. Chem. 2015, 90, 241-250. (IF 5.572)