高顶顶
博士 副研究员
创新中药研究院 手性药物研究中心
上海中医药大学
地址:上海市浦东新区蔡伦路1200号
电话:
gaodingding@shutcm.edu.cn
研究内容
基于靶标的创新药物研究
工作经历
2021.1−目前
副研究员, 上海中医药大学 创新中药研究院 手性药物研究中心
2020.7−2020.12
助理研究员, 上海中医药大学 创新中药研究院 手性药物研究中心
2018.7−2020.6
师资博士后, 上海中医药大学 合作导师:林国强 研究员(院士)
教育背景
2012.9-2018.6
博士,复旦大学 药学院,药物化学专业 (导师:李英霞 教授)
2008.9−2012.6
本科,郑州大学 药学院,药物制剂专业
学术荣誉
上海中医药大学“杏林青年学者” 2020
上海中医药大学“十大杏林菁英” 2020
上海市青年科技英才“扬帆计划” 2019
主持科研项目
1. 中国博士后科学基金面上项目(2018M642064)
2. 上海市青年科技英才扬帆计划(19YF1449300,2019.05−2022.04)
3. 国家自然科学基金青年基金(81903423,2020.01−2022.12)
4. 上海中医药大学预算内项目(A1-GY0309)
代表性论文
11. Jia-Ying Zhao, Kai-Rui Feng, Feng Wang, Jian-Wei Zhang, Jay Fei Cheng,* Guo-Qiang Lin, Dingding Gao,* and Ping Tian* A Retrospective Overview of PHGDH and Its Inhibitors for Regulating Cancer Metabolism. Eur. J. Med. Chem. 2021,217, 113379. (IF 5.572)
10. Qing-Hua Li,# Dingding Gao,# Cheng-Yu He, Qi Liao, Yun-Xuan Tan, Yu-Hui Wang,* Rui Ding,* Guo-Qiang Lin, and Ping Tian* One-Pot Preparation of Bridged Tricyclic and Fused Tetracyclic Scaffolds via Rhodium(III)-Catalyzed Asymmetric Borylative Cyclization. Cell Reports Physical Science 2020,1, 100222.
9.Cheng-Yu He#, Yun-Xuan Tan#, Xin Wang, Rui Ding, Yi-Fan Wang, Feng Wang, Dingding Gao*, Ping Tian *, and Guo-Qiang Lin* Copper(I)-Catalyzed Diastereo- and Enantioselective Construction of Optically Pure Exocyclic Allenes. Nat. Commun. 2020, 11, 4293. (IF 12.121)
8.Dingding Gao#, Xing-Yu Liu#, Hao Xu#, Yun-Xuan Tan, Qi Liao, Qing-Hua Li*, Xiaodi Yang, Guo-Qiang Lin*, and Ping Tian* One-Pot Preparation of 9,10-Dihydrophenanthrenes Initiated by Rhodium(III)-Catalyzed C−H Activation and Relay Diels-Alder Reaction. Org. Lett. 2020, 22, 4300−4305. (IF 6.091)
7.Kai-Rui Feng#, Feng Wang#, Xin-Wei Shi, Yun-Xuan Tan, Jia-Ying Zhao, Jian-Wei Zhang, Qing-Hua Li*, Guo-Qiang Lin, Dingding Gao*, and Ping Tian* Design, synthesis and biological evaluation of novel potent STAT3 inhibitors based on BBI608 for cancer therapy. Eur. J. Med. Chem., 2020, 201, 112428. (IF 5.572)
6.Dingding Gao#, Feng Wang#, Xing-Yu Liu, Kai-Rui Feng, Jia-Ying Zhao, Yu-Hui Wang*, Xiao-Di Yang*, Ping Tian*, and Guo-Qiang Lin Synthesis of Decahydrocyclobuta[cd]indene Skeleton: Rhodium(III)-Catalyzed Hydroarylaton and Relay Thiophene-Promoted Intramolecular [2 + 2] Cycloaddition. Adv. Synth. Catal. 2020, 362, 4384–4390. (IF 5.851)
5.Jun-Li Zhang#, Dingding Gao#, Yun-Xuan Tan, Cheng-Yu He, Pei-Ying Peng, Guo-Qiang Lin, Qing-Hua Li*, Ping Tian* Rhodium(III)-Catalyzed Kinetic Resolution of Racemic 1,6-Dienes via Asymmetric Borylative Cyclization. Org. Lett. 2020, 22, 3661-3666. (IF 6.091)
4.Ming-Shun Mei#, Yu-Hui Wang#, Qing Hu, Qing-Hua Li, Da-Yu Shi, Dingding Gao,* Guangbo Ge,* Guo-Qiang Lin, and Ping Tian* Enantioselective [3 + 2] Annulation of Isatin-Derived MBH-Carbonates and 3-Nitroindoles Enabled by a Bifunctional DMAP-Thiourea. Chem. Commun. 2020, 56, 10718-10721. (IF 5.996)
3.Bingbing Zhang#, Jiami Liu#, Dingding Gao#, Xiaolin Yu, Jinlei Wang, Xinsheng Lei* A fluorine scan on the Zn2+-binding thiolate side chain of HDAC inhibitor largazole: Synthesis, biological evaluation, and molecular modeling. Eur. J. Med. Chem. 2019, 182, 111672. (IF 5.572)
2.Dingding Gao#, Huixia Dou#, Haixia Su#, Mingming Zhang#, Ting Wang, Qiufeng Liu, Haiyan Cai, Zhuo Yang, Weiliang Zhu*, Yechun Xu*, Heyao Wang*, Yingxia Li* From Hit to Lead: Structure-based Discovery of Naphthalene-1-Sulfonamide Derivatives as Potent and Selective Inhibitors of Fatty Acid Binding Protein 4. Eur. J. Med. Chem. 2018, 154, 44-59. (IF 5.572)
1.Haiyan Cai#, Qiufeng Liu#, Dingding Gao#, Ting Wang, Tiantian Chen,Guirui Yan, Kaixian Chen, Yechun Xu*, Heyao Wang*, Yingxia Li*, Weiliang Zhu* Novel fatty acid binding protein 4 (FABP4) inhibitors: Virtual screening, synthesis and crystal structure determination. Eur. J. Med. Chem. 2015, 90, 241-250. (IF 5.572)