李清华 博士 副研究员
创新中药研究院 手性药物研究中心
上海中医药大学
地址:上海市浦东新区蔡伦路1200号
电话:(+86)-21-5132 8954
邮箱:qinghuali@shutcm.edu.cn
研究内容
基于手性强酸和过渡金属协同的不对称催化
面向临床诊断的荧光探针的设计与合成
中药活性单体结构修饰与构效关系研究
工作经历
2022.1−目前
副研究员 上海中医药大学,创新中药研究院
2019.12−2021.12
助理研究员 上海中医药大学,创新中药研究院
2017.9−2019.11
博士后 上海中医药大学,创新中药研究院
2016.5−2017.8
博士后 香港浸会大学 化学系,合作导师:Professor Beng Ong
2013.12−2016.4
博士后 香港浸会大学 化学系,合作导师:Professor Albert Lee Wai-ming
教育背景
2010.6-2013.11
香港浸会大学 化学系 硕士-博士 导师:Professor Albert Lee Wai-ming
2001.9−2005.6
青岛大学 应用化学系 本科
主持科研项目
上海市自然科学基金面上项目(21ZR1460700,2021.07−2024.06)
上海中医药大学预算内项目(18LK018)
代表性论文
10. Qing-Hua Li,# Gui-Shan Zhang,# Feng Wang, Yixin Cen, Xi-Liang Liu, Jian-Wei Zhang, Yu-Hui Wang,* Albert W. M. Lee,* Dingding Gao,* Guo-Qiang Lin, and Ping Tian* Nature-Inspired Catalytic Asymmetric Rearrangement of Cyclopropylcarbinyl Cation. Sci. Adv. 2023, 9, eadg1237. (IF 13.6)
9. Dingding Gao,#* Shuai Tang,# Yixin Cen,# Liang Yuan, Xiaojing Lan, Qing-Hua Li,* Guo-Qiang Lin, Min Huang,* and Ping Tian* Discovery of Novel Drug-like PHGDH Inhibitors to Disrupt Serine Biosynthesis for Cancer Therapy. J. Med. Chem. 2023, 66, 285. (IF 7.3)
8. Hao Xu,# Yun-Xuan Tan,# Pei-Pei Xie,# Rui Ding, Qi Liao, Jian-Wei Zhang, Qing-Hua Li,* Yu-Hui Wang,* Xin Hong,* Guo-Qiang Lin, and Ping Tian* Rhodium(III)-Catalyzed Asymmetric Reductive Cyclization of Cyclohexadienone-Containing 1,6-Dienes via an Anti-Michael/ Michael Cascade Process. ACS Catal. 2021, 11, 8015−8022. (IF = 12.350)
7. Qing-Hua Li,# Dingding Gao,# Cheng-Yu He, Qi Liao, Yun-Xuan Tan, Yu-Hui Wang,* Rui Ding,* Guo-Qiang Lin, and Ping Tian* One-Pot Preparation of Bridged Tricyclic and Fused Tetracyclic Scaffolds via Rhodium(III)-Catalyzed Asymmetric Borylative Cyclization. Cell Reports Physical Science 2020,1, 100222.
6. Dingding Gao#, Xing-Yu Liu#, Hao Xu#, Yun-Xuan Tan, Qi Liao, Qing-Hua Li*, Xiaodi Yang, Guo-Qiang Lin*, and Ping Tian* One-Pot Preparation of 9,10-Dihydrophenanthrenes Initiated by Rhodium(III)-Catalyzed C−H Activation and Relay Diels-Alder Reaction. Org. Lett. 2020, 22, 4300−4305. (IF 6.091)
5. Jun-Li Zhang,# Dingding Gao,# Yun-Xuan Tan, Cheng-Yu He, Pei-Ying Peng, Guo-Qiang Lin, Qing-Hua Li,* and Ping Tian* Rhodium(III)-Catalyzed Kinetic Resolution of Racemic 1,6-Dienes via Asymmetric Borylative Cyclization. Org. Lett. 2020, 9, 3661−3666. (IF 6.091)
4.Kai-Rui Feng#, Feng Wang#, Xin-Wei Shi, Yun-Xuan Tan, Jia-Ying Zhao, Jian-Wei Zhang, Qing-Hua Li*, Guo-Qiang Lin, Dingding Gao*, and Ping Tian* Design, synthesis and biological evaluation of novel potent STAT3 inhibitors based on BBI608 for cancer therapy. Eur. J. Med. Chem. 2020, 201, 112428. (IF 5.572)
3. Cheng-Yu He,# Qing-Hua Li,# Xin Wang, Feng Wang, Ping Tian,* and Guo-Qiang Lin* The Selective Borylation Occurs at Electron-Rich Alkenes Rather Than Electron-Deficient Alkenes: Cu-Catalyzed Asymmetric Borylative Cyclization of 1,6-Dienes. Adv. Synth. Catal. 2019, 362, 765−770. (IF 5.851)
2. Qing-Hua. Li,# Gui-Shan Zhang,# Yu-Hui Wang, Ming-Shun Mei, Xin Wang, Qiang Liu,* Xiao-Di Yang, Ping Tian,* and Guo-Qiang Lin A novel chiral DMAP–thiourea bifunctional catalyst catalyzed enantioselective Steglich and Black rearrangement reactions. Org. Chem. Front. 2019, 6, 2624−2629. (IF 5.155)
1. Qinghua Li, Wai Yeung Wong, Wing Hong Chan, Albert W. M. Lee* Second Generation CaSH (Camphor Sulfonyl Hydrazine) Organocatalysis: Asymmetric Diels-Alder Reactions and Isolation of the Catalytic Intermediate. Adv. Synth. Catal. 2010, 352 (13), 2142−2146. (IF 5.851)