李清华

博士 助理研究员

创新中药研究院 手性药物研究中心

上海中医药大学

上海市浦东新区蔡伦路1200号

电话:(+86)-21-5132 8954

qinghuali@shutcm.edu.cn

  • 研究内容

    • 基于手性强酸和过渡金属协同的不对称催化

    • 面向临床诊断的荧光探针的设计与合成

    • 中药活性单体结构修饰与构效关系研究

  • 工作经历

    • 2019.12−目前

      助理研究员  上海中医药大学,创新中药研究院

    • 2017.9−2019.11

      博士后  上海中医药大学,创新中药研究院

    • 2016.5−2017.8

      博士后  香港浸会大学 化学系,合作导师:Professor Beng Ong

    • 2013.12−2016.4

      博士后  香港浸会大学 化学系,合作导师:Professor Albert Lee Wai-ming

  • 教育背景

    • 2010.6-2013.11

      香港浸会大学  化学系   硕士-博士  导师:Professor Albert Lee Wai-ming

    • 2001.9−2005.6

      青岛大学   应用化学系   本科

  • 科研项目

    • 上海中医药大学预算内项目,项目编号:18LK018,项目负责人:李清华,

  • 代表性论文

    • 7.Qing-Hua Li,# Dingding Gao,# Cheng-Yu He, Qi Liao, Yun-Xuan Tan, Yu-Hui Wang,* Rui Ding,* Guo-Qiang Lin, and Ping Tian*   One-Pot Preparation of Bridged Tricyclic and Fused Tetracyclic Scaffolds via Rhodium(III)-Catalyzed Asymmetric Borylative Cyclization. Cell Reports Physical Science 2020,1, 100222.

    • 6.Dingding Gao#, Xing-Yu Liu#, Hao Xu#, Yun-Xuan Tan, Qi Liao, Qing-Hua Li*, Xiaodi Yang, Guo-Qiang Lin*, and Ping Tian*   One-Pot Preparation of 9,10-Dihydrophenanthrenes Initiated by Rhodium(III)-Catalyzed C−H Activation and Relay Diels-Alder Reaction. Org. Lett. 202022, 4300−4305. (IF 6.091)

    • 5.Jun-Li Zhang,# Dingding Gao,# Yun-Xuan Tan, Cheng-Yu He, Pei-Ying Peng, Guo-Qiang Lin, Qing-Hua Li,* and Ping Tian*   Rhodium(III)-Catalyzed Kinetic Resolution of Racemic 1,6-Dienes via Asymmetric Borylative Cyclization. Org. Lett. 20209, 3661−3666. (IF 6.091)

    • 4.Kai-Rui Feng#, Feng Wang#, Xin-Wei Shi, Yun-Xuan Tan, Jia-Ying Zhao, Jian-Wei Zhang, Qing-Hua Li*, Guo-Qiang Lin, Dingding Gao*, and Ping Tian*  Design, synthesis and biological evaluation of novel potent STAT3 inhibitors based on BBI608 for cancer therapy. Eur. J. Med. Chem. 2020201, 112428. (IF 5.572)

    • 3.Cheng-Yu He,# Qing-Hua Li,# Xin Wang, Feng Wang, Ping Tian,* and Guo-Qiang Lin*  The Selective Borylation Occurs at Electron-Rich Alkenes Rather Than Electron-Deficient Alkenes: Cu-Catalyzed Asymmetric Borylative Cyclization of 1,6-Dienes. Adv. Synth. Catal. 2019, 362, 765−770. (IF 5.851)

    • 2.Qing-Hua. Li,# Gui-Shan Zhang,# Yu-Hui Wang, Ming-Shun Mei, Xin Wang, Qiang Liu,* Xiao-Di Yang, Ping Tian,* and Guo-Qiang Lin  A novel chiral DMAP–thiourea bifunctional catalyst catalyzed enantioselective Steglich and Black rearrangement reactions. Org. Chem. Front. 2019, 6, 2624−2629. (IF 5.155)

    • 1.Qinghua Li, Wai Yeung Wong, Wing Hong Chan, Albert W. M. Lee*  Second Generation CaSH (Camphor Sulfonyl Hydrazine) Organocatalysis: Asymmetric Diels-Alder Reactions and Isolation of the Catalytic Intermediate. Adv. Synth. Catal. 2010, 352 (13), 2142−2146. (IF 5.851)